• 03 APR 16
    • 13

    1820.001 US PATENT NO. 7754237

    (54) TRANSDERMAL THIAMINE INSECT 5,021,424 A 6/1991 Lamon_wal1REPELLANT 5,899,856 A * 5/1999 schoendorfer ct a1. …. ,. 600/352

    (76) Inventor: Robert E.Borland,Jr., l2l58 Highway 5’965’137 A * l0′:1999 Pe_LmS23] NOHIL Pinckard! AL (US) 36371 6,010,715 A 12000 wick etal. ……………. .. 424/4486,475,514 B1 * 11/2002 Blitzer et al. …………. 4. 424/449( * ) Notice: Subject to any disclaimer, the tem of this 6,719,997 B2 4/2004 Hsn et a1.patent is extended or adjusted under 35 6358.200 B2 2/2005 FowlerUSC 15403) by 259 days‘ 2005/0008656 A1 1/2005 Mereditlt

    1. Field ofthe InventionThis invention relates to methods for repelling insects and,I5 more particularly, to the transdemial systemic delivery ofthiamine to repel insects,2. Technical BackgroundInsect repellants are useful for preventing insects frombiting the skin, especially mosquitoes. Most of the knowninsect repellents that are topically applied to deter mosquitoesfrom biting consist of chemical compositions consisting of:N, N—dietltyl toluamide (DEET), N, N—diethyl benzamide,dimethyl phytate, ethyl bexanediol, indalone. di-n-propyl-isocinchoronate, bicycloheptene dicarboxide, tetrahydrofuraldehyde, among others. DEBT, the most popular, is toxic2025cally (into the blood stream) uses a topical or transdemial“patch,” wherein the thianline is contained within a smlcturethat is to he affixed to the skin. In such a structure, thethiamine is contained in a layer, or “reservoir,” underlying anupper backing layer. The reservoir has a polyrneric matrix ofa pharmaceutically acceptable adhesive material that servesto affix the system to the skin during thiamine delivery, Theadhesive material is usually a pressure-sensitive adhesive(PSA) that is suitable for long-terrn skin contact, and whichshould be physically and chemically compatible with thia-mine, and any carriers, vehicles or other additives that arepresent. Examples of suitable adhesive materials include. butare not limited to, the following: polyethylenes; po1ysilox—

    Full Report:

    1820.001 US PATENT NO. 7754237

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