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    Electronic Filing System ID 19803964

    PCT Patent Application Number PCT/US14/50096
    Electronic Filing System ID 19803964 International Application Number PCT/US14/50096 Confirmation Number 3202 Title of Invention TRANSDERMAL THIAMINE INSECT REPELLENT First Named Inventor/Applicant Name Robert, Jr E. BORLAND Filing Firm’s Customer Number 062439 Attorney Docket Number TPC20075 Receipt Date 07-AUG-2014 Time Stamp 14:44:46 Application Type International Application for filing in the US receiving office Documents Filed Specification Figures Fee Worksheet

    Transdermal Thiamine Insect Repellent
    OVERVIEW OF THE INVENTION

    1. Scope of the Invention
    The invention provides a method to ward off various insects through transdermal application of a 5 patch containing thiamine.

    2. Contextual Background
    The primary task of insect repellants is to ward off insects, specifically mosquitoes, from contacting and biting the skin. Traditional insect repellants that are available in the market contain a number of chemicals such as bicycloheptene dicarboxide, tetrahydro furaldehyde, N-10 diethyl benzamide, N-diethyl toluamide (DEET), ethyl bexanediol, di-n-propylisocinchoronate, indalone, dimethyl phytate and various others. N-diethyl toluamide (DEET) is the most common chemical found in most insect repellents. However, DEET is toxic to the skin with various side effects that include mild skin irritation, mood swings, and even seizures. Apart from DEET, Indalone and ethyl bexanediol are also harmful for the people. A number of reports have pointed 15 out that insect repellant containing either of these to chemicals cause kidney and liver damage on continued usage.
    Apart from adverse side effects of traditional insect repellants, they also leave an unpleasant oily or greasy residue on the skin. The residue produces a peculiar unpleasant smell that emanates from the body. 20 Although there are natural non-chemical ways of warding off insects from the skin, they are not without their short comings. For instance, garlic is known to be a natural insect repellant. Yet it produces a very unpleasant smell that emanates from the mouth after ingestion. It also provides only marginal protection against insects. Another natural method to repel insects is oral application of thiamine (vitamin B1). Thiamine is then emitted by the sweat glands that repel 25 insects. However, oral administration of thiamine is not that effective in warding off insects from 2 the skin. The reason is that gastrointestinal absorption is a variable that lowers the thiamine concentration on extraction from the liver. In order to increase effectiveness of oral administration of thiamine, it is necessary to intake other items such as Vitamin C plus biotin, or garlic, or other herbs to repel insects from the skin. This necessitates the effective way to repel insects that results in less adverse effects on the body. 5 The solution to the problem rests in systematic delivery of thiamine ingredients that provide long term protection against insects without having the need to intake other items.

    3. Invention Summary
    The invention provides an effective way to ward off insects through transdermal application of thiamine in the form of a skin patch. The transdermal patch contains around 50 mg of thiamine 10 as well as Ginko. It consists of a thin film backing that serves as an occlusive support membrane. One side of this film contains a pressure sensitive coating of thiamine. Thiamine is dispersed into an adhesive resin that is protected by a liner. This liner is removed from the adhesive upon administration of the patch to a clean, hairless, dry part of the skin. The Ginko assists in the process of Thiamine entering the Bloodstream through its vasodilation properties. 15 Upon application to the skin, it takes up to 2 hours to provide protection against the insect. The patch is worn for about 24 – 48 hours during which it will continue to repel biting insects, especially mosquitoes, fleas, flies, and midges. After the patch is removed from the skin, it provides protection for 6 hours more before requiring another transdermal application of the patch. 20 Some of the advantages of this invention that relates to transdermal administration of thiamine containing patch include the following:

    • It repels insects by a quick and systematic delivery of thiamine directly into the
      bloodstream via the skin.
    • It is a natural and safe way to ward off insects. 25
    • It provides 30 – 54 hours protection against insects.
    • It repels insects without the need to apply ointments and oily creams that result in unpleasant odors.
    • It is simple to manufacture and produce.
    • It is easy to administer and use.

     

    Link to Full Patent Disclosure:

    PCT Patent Filing

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